Viral Retinopathy in Experimental Models of Zika Infection

Viral Retinopathy in Experimental Models of Zika Infection

Purpose Emerging evidence has shown that both congenital and adult Zika virus (ZIKV) infection can cause eye diseases. The goals of the current study were to explore mechanisms and pathophysiology of ZIKV-induced eye defects. Methods Wild-type or A129 interferon type I receptor-deficient mice were infected by either FSS13025 or Mex1-7 strain of ZIKV. Retinal histopathology was measured at dif...

Zika-related microcephaly in experimental models

First discovered in 1947, the Zika virus is an arbovirus of the Flaviviridae family, that has not been reported to cause human disease until 2007 when the first outbreak took place in the Yap State, Micronesia. Patients referred fever, joint pain, cutaneous rashes and conjunctivitis. A few years later, in 2014, another outbreak in French Polynesia highlighted the relevance of the new agent that...

Zika Virus Infection after Returning from Thailand

Understanding the Pathogenesis of Zika Virus Infection Using Animal Models

Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental ...

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity.

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and in...